Cracking your knuckles (or any of your joints) can have therapeutic benefits. When you crack one of your joints you are pulling the bones that are connected at the joint apart from each other. This process stimulates your tendons, relaxes your muscles, and loosens your joints. Chiropractors do this for spinal joints when your back is sore and stiff, but you can do this on your own for your knuckles, toes, knees, neck, etc.
Unfortunately, there can be too much of a good thing.(despite what your mom keeps telling you), but scientists have discovered that it can cause tissue damage in the affected joints. Knuckle-cracking pulls your finger bones apart which stretches your ligaments. In addition to making your hand really sore, this ligament damage can also result in reduced grip strength.
How does this work? Your joints, the places in your body where you can bend, are where your bones intersect and are held together by ligaments. These joints are surrounded by a liquid called synovial fluid. When you stretch your ligaments by pulling the bones apart to crack your knuckles a gas in the synovial fluid escapes and turns into a bubble. This process is called cavitation. Cavitation ends when the bubble eventually bursts, producing that popping sound we know and love. After that, your joints won't be able to crack for another 25-30 minutes while the gas gets reabsorbed into the synovial fluid.